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trappsol® (hydroxypropyl beta cyclodextrin  (CDT Inc)

 
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    CDT Inc trappsol® (hydroxypropyl beta cyclodextrin
    Trappsol® (Hydroxypropyl Beta Cyclodextrin, supplied by CDT Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/trappsol%C2%AE+%28hydroxypropyl+beta+cyclodextrin%29/us10835533-602-18-22?v=CDT+Inc
    Average 90 stars, based on 1 article reviews
    trappsol® (hydroxypropyl beta cyclodextrin - by Bioz Stars, 2026-07
    90/100 stars

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    Summary of riluzole IT formulations.

    Journal: PLOS ONE

    Article Title: Spinal cord and brain concentrations of riluzole after oral and intrathecal administration: A potential new treatment route for amyotrophic lateral sclerosis

    doi: 10.1371/journal.pone.0277718

    Figure Lengend Snippet: Summary of riluzole IT formulations.

    Article Snippet: For IT administration, riluzole was formulated in Trappsol Cyclo or Trappsol® Hydroxypropyl Beta Cyclodextrin Endotoxin Controlled (THPB-EC ; CTD Holdings, Inc., Alachua, FL) to increase the drug solubility.

    Techniques:

    Animals were treated with A: IT saline, B: IT vehicle, C: oral riluzole, D: oral + IT riluzole (0.05 mg/h), E: oral + IT riluzole (0.1 mg/h) and F: oral + IT riluzole (0.2 mg/h). Magnification as indicated. The cyclodextrin THPB-EC vehicle was associated with exacerbated catheter track inflammatory reactions as compared to the saline controls. The spinal cord of animals treated with oral riluzole only (C) were histologically within normal limits. Animals treated with IT riluzole showed equivocal, slight increases in SC degeneration (not visible here) compared to vehicle controls.

    Journal: PLOS ONE

    Article Title: Spinal cord and brain concentrations of riluzole after oral and intrathecal administration: A potential new treatment route for amyotrophic lateral sclerosis

    doi: 10.1371/journal.pone.0277718

    Figure Lengend Snippet: Animals were treated with A: IT saline, B: IT vehicle, C: oral riluzole, D: oral + IT riluzole (0.05 mg/h), E: oral + IT riluzole (0.1 mg/h) and F: oral + IT riluzole (0.2 mg/h). Magnification as indicated. The cyclodextrin THPB-EC vehicle was associated with exacerbated catheter track inflammatory reactions as compared to the saline controls. The spinal cord of animals treated with oral riluzole only (C) were histologically within normal limits. Animals treated with IT riluzole showed equivocal, slight increases in SC degeneration (not visible here) compared to vehicle controls.

    Article Snippet: For IT administration, riluzole was formulated in Trappsol Cyclo or Trappsol® Hydroxypropyl Beta Cyclodextrin Endotoxin Controlled (THPB-EC ; CTD Holdings, Inc., Alachua, FL) to increase the drug solubility.

    Techniques: Saline

    Animals were treated with A: IT saline, B: IT vehicle, C: oral riluzole, D: oral + IT riluzole (0.1 mg/h), E: oral + IT riluzole (0.2 mg/h) and F: oral + IT riluzole (0.4 mg/h). Magnification as indicated. The cyclodextrin THPB-EC vehicle was associated with exacerbated catheter track inflammatory reactions as compared to saline controls. The spinal cord of animals treated with oral riluzole only (C) were histologically within normal limits. Animals treated with 0.1 or 0.2 mg/h IT riluzole showed increases in SC degeneration (not visible here) compared to vehicle controls. Animals treated with 0.4 mg/h IT riluzole sowed additional exacerbations of catheter track inflammatory reactions and inflammatory changes in the parenchyma of the spinal cord (visible here).

    Journal: PLOS ONE

    Article Title: Spinal cord and brain concentrations of riluzole after oral and intrathecal administration: A potential new treatment route for amyotrophic lateral sclerosis

    doi: 10.1371/journal.pone.0277718

    Figure Lengend Snippet: Animals were treated with A: IT saline, B: IT vehicle, C: oral riluzole, D: oral + IT riluzole (0.1 mg/h), E: oral + IT riluzole (0.2 mg/h) and F: oral + IT riluzole (0.4 mg/h). Magnification as indicated. The cyclodextrin THPB-EC vehicle was associated with exacerbated catheter track inflammatory reactions as compared to saline controls. The spinal cord of animals treated with oral riluzole only (C) were histologically within normal limits. Animals treated with 0.1 or 0.2 mg/h IT riluzole showed increases in SC degeneration (not visible here) compared to vehicle controls. Animals treated with 0.4 mg/h IT riluzole sowed additional exacerbations of catheter track inflammatory reactions and inflammatory changes in the parenchyma of the spinal cord (visible here).

    Article Snippet: For IT administration, riluzole was formulated in Trappsol Cyclo or Trappsol® Hydroxypropyl Beta Cyclodextrin Endotoxin Controlled (THPB-EC ; CTD Holdings, Inc., Alachua, FL) to increase the drug solubility.

    Techniques: Saline